Induction of microsomal enzymes by this drug, may well shorten the half-lifetime of doxycycline for so long as 2 weeks immediately after barbiturate therapy discontinued; watch medical reaction to doxycycline closely if both of those drugs administered concurrently
pentobarbital will minimize the extent or outcome of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Watch Closely (1)pentobarbital will decrease the level or result of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, lack of efficacy or, quite possibly, advancement of a withdrawal syndrome in the affected person who's got formulated Actual physical dependence to fentanyl. Following stopping a CYP3A4 inducer, as being the effects from the inducer drop, the fentanyl plasma focus will raise which could improve or prolong the two the therapeutic and adverse effects.
pentobarbital will lower the extent or effect of carvedilol by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.
pentobarbital will lessen the extent or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.
pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers more info can cut down panobinostat degrees by ~70% and cause cure failure.
Both improves toxicity of the other by pharmacodynamic synergism. Prevent or Use Alternate Drug. Profound sedation, respiratory despair, coma, and death could consequence if coadministered. Reserve concomitant prescribing of such drugs in people for whom other remedy selections are insufficient. Limit dosages and durations for the minimal essential. Watch carefully for signs of respiratory despair and sedation.
pentobarbital will reduce the level or outcome of methylprednisolone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the extent or impact of stiripentol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If unable to prevent coadministration of stiripentol with solid CYP3A4 inducers, boost stiripentol dose.
pentobarbital will lessen the extent or impact of cevimeline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
fentanyl transmucosal and pentobarbital both of those increase sedation. Stay away from or Use Alternate Drug. Restrict use to people for whom alternate cure solutions are inadequate
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Also immediate administration may possibly cause respiratory depression, laryngospasm, apnea, or vasodilation with drop in blood pressure level
pentobarbital will reduce the level or result of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.